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MEDI4166 demonstrates extended glucose control, delays development of diabetes and reduces obesity in rodent models To investigate if the optimised in vivo stability and reduced potency of the MEDI4166 GLP-1 peptide component translates into prolonged glucose control, we compared the impact of MEDI4166 and exendin-4 in fusion with the same antibody partner (Ab#2.1_EX4) on fasting plasma glucose (FPG) levels in moderately hyperglycaemic diet-induced obese (DIO) mice over 21 days (Fig

These cardiovascular benefits make semaglutide particularly valuable for people with obesity who face increased heart disease risk

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[1] It is prepared in a 30 mL multi-dose vial with a preservative (2 % benzyl alcohol) for multiple withdrawals