Hypoxia stress was modeled by placing rats into a flow pressure chamber for 15 minutes under 0.26 bar, which simulates an altitude of 10,000 m above ground level
& Klionsky, D
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This metabolic dysregulation leads to an increased mobilization and subsequent influx of free fatty acids (FFAs) into the liver, thereby promoting the accumulation of TG and the development of hepatic steatosis
J Clin Invest 114(1):514 Zhang Q, Kulczynska A, Webb DJ, Megson IL, Botting NP (2013) A new class of NO-donor pro-drugs triggered by gamma-glutamyl transpeptidase with potential for reno-selective vasodilatation