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MMK treatment (0.25 g/kg per day for 14 days) reduced 1% evans blue dye leakage in both mouse models, sneezing and blood eosinophil count in guinea pigs, attenuated plasma histamine, protected RBCs, and inhibited CHO intracellular calcium release [65]

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Production of antimicrobial peptides and reactive oxygen species (ROS): When mast cells degranulate, they release molecules such as antimicrobial peptides and reactive oxygen species that damage and neutralize invading microbes

10.1016/j.bbamcr.2010.09.019 258 SchakelL.VeldhuijzenD

Gradual dose increases are crucial for managing potential gastrointestinal side effects