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In addition to slowing down gastric emptying, GLP-1 medications like semaglutide can also affect the brain, regulating your appetite, increasing feelings of fullness , and decreasing f ood noise . But studies of animals suggest that semaglutides effect on the brain can also produce a nausea response
PLoS One 14, e0222613
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If those factors are not addressed, weight loss may be slower than expected
Smith SEP, Li J, Garbett K, Mirnics K, Patterson PH
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