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What the clinical evidence shows Several large, peer-reviewed studies have quantified the risk: The STEP 1 trial (NEJM, 2021): patients on high-dose semaglutide lost an average of 14.9% of their body weight over 68 weeks

Last year, Nestl launched an entire GLP-1-friendly food product line, explicitly designed for people taking these medications

Among adults with obesity and type 2 diabetes, 10.1% receiving semaglutide and 5.4% receiving placebo stopped using lipid-lowering therapy at 68 weeks

That combination is why people tend to eat less on low-carb without consciously trying to

In addition, age dependent accretion of dysfunctional mitochondria elevates stress level, which is exhibited by high levels oxidized products such as protein carbonyls and lipid peroxides 42

Additionally, GLP-1 receptor agonists influence vascular autoregulation and may alter the delicate balance of blood flow control in susceptible individuals with anatomical risk factors