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Thus, for a number of them, even if they are good substrates in vitro , other clearance pathways may be more important in vivo or, if they are cleaved by DPP-4, removal of the N-terminal dipeptide may have no effect upon their biological activity

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The system needs to move faster, and in the meantime, the people advising patients need to be very clear about the legal and safety risks of unregulated sources

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