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Abruptly discontinuing the medication without guidance could lead to a rise in blood sugar levels or other complications
Peptides are short chains of amino acids that act as signaling molecules in the body, instructing cells to perform specific functions such as collagen production, fat metabolism, or muscle repair
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Obesity with hepatic steatosis : Patients with BMI 30 kg/m (or 27 kg/m with weight-related comorbidities) and documented fatty liver may benefit from GLP-1 agonists approved for chronic weight management
DIO-MASH: Open symbols show pretreatment values
In the Phase 2 obesity trial published in NEJM in 2023, retatrutide at the 12 mg weekly dose produced a mean placebo-adjusted body weight reduction of 22.1 percentage points (22.1% (24.2% arm) mean absolute reduction on the retatrutide arm) at 48 weeks (Jastreboff et al., NEJM, 2023)
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