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Furthermore, lixisenatide can cross the BBB at very low doses with obvious physiological activity, and promote neurogenesis in the CNS ( Along with T2DM-induced hyperglycemia, cerebral blood flow (CBF) is obviously decreased on account of regulation of vasculature and vasoactive mediators, especially endothelium-derived nitric oxide (NO) (161)
Some patients may experience minimal disruption, particularly if the delay is brief, while others notice more pronounced effects on appetite and glycemic control
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As a result of using Defendants Ozempic and Mounjaro, Plaintiff was caused to suffer from severe gastrointestinal events, which resulted in, for example, severe vomiting, stomach pain, gastrointestinal burning, being hospitalized for stomach issues on several occasions including visits to the emergency room, teeth falling out due to excessive vomiting, requiring additional medications to alleviate her excessive vomiting, and throwing up whole food hours after eating. The lawsuit explains: Defendants acknowledge that gastrointestinal events are well known side effects of the GLP-1 class
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