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If participants on CagriSema maintain higher energy expenditure after stopping treatment compared to participants on tirzepatide, the weight regain trajectory could differ meaningfully
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Despite the substantial conformational dynamics when bound to AMY 3 R, Cagri maintains the bypass conformation across the motions, likely arising from the consistent TMD and linker interactions between RAMP3 and CTR that enable robust engagement of residues within the Cagri bypass motif
B 2 , 1190 (2014)
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