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Any intervention producing significant weight loss, whether dietary, surgical, or pharmaceutical, carries elevated gallstone risk

Clinically meaningful responses in insulin-resistant patients typically include a reduction in fasting insulin of 20-40% and an improvement in HOMA-IR within 8-12 weeks at therapeutic doses, though individual variability is wide [1]

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Or, more likely, it could be that their effects are both interfering with that of BPC 157

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This mechanism naturally limits absorption when B12 is consumed in large quantities, with excess amounts typically eliminated through the kidneys without causing harm