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The result can be increased shedding several months after beginning treatment or experiencing significant weight loss
Goel typically recommends a loading protocol (35 sessions over 12 weeks) followed by monthly maintenance
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Pulse-chase analysis addresses this directly
Mice deficient in endothelial NO synthase (eNOS), the key enzyme for NO production in vessels, are characterized by faster erythrocyte clearance, possibly due to enhanced erythrocyte PS exposure and subsequent phagocytosis [170]
Manufacturing scale-up issues could also create delays
