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should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus Discontinue treatment in women at least 2 months before a planned pregnancy, owing to the long washout period for semaglutide Clinical Considerations Poorly controlled diabetes during pregnancy increases maternal risk for diabetic ketoacidosis, preeclampsia, spontaneous abortions, preterm delivery, stillbirth, and delivery complications Poorly controlled diabetes increases fetal risk for major birth defects, stillbirth, and macrosomia-related morbidity Lactation There are no data on the presence of semaglutide in human milk, the effects on the breastfed infant, or the effects on milk production In lactating rats, semaglutide was detected in milk at levels 3- to 12-fold lower than in maternal plasma Interactions Coadministration with insulin secretagogues (eg, sulfonylureas) or insulin may increase the risk of hypoglycemia
Nevertheless, the consistency of preclinical findings has fueled optimism that GLP-1based therapies may ultimately find uses far beyond diabetes and obesity
Elle a relev que les poudres utilises pour le compoundage de solutions injectables prsentaient des risques de contamination par des endotoxines
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adverse effects were broadly consistent with GI tolerability known for GLP-1/dual agonists, with higher discontinuation during rapid dose escalation
