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L'activation du MC1R par le MT-2 dclenche une cascade adenylate-cyclase-AMPc-PKA-CREB-MITF qui culmine dans la stimulation transcriptionnelle du gne de la tyrosinase, enzyme clef de la mlanogense

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So I can, like you said, slowly and incrementally increase

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Matveyenko AV, Dry S, Cox HI, Moshtaghian A, Gurlo T, Galasso R, Butler AE, and Butler PC