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Because the metabolic foundation was never rebuilt, appetite returns, dysbiosis persists, SCFAs remain low, and circadian signals remain disrupted
Each person brings unique factors like medical history, weight goals, and overall health
This weekly regimen is based on the drug's pharmacokinetic profile, with a half-life of approximately one week (approximately 165 hours), which allows for steady-state plasma concentrations to be maintained with weekly administration
10.1056/NEJM199807233390404
The landmark STEP 1 trial for semaglutide, published in The New England Journal of Medicine , provided crucial insight into this issue
This is independent of the semaglutide question
