Testicular torsion and spermatogenesis
Yes, phentermine has been FDA-approved since 1959 and has been widely prescribed as a weight loss drug in the United States
In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (5, 6, 42)
What is particularly notable about the CagriSema combination is the much better side effect profile while still retaining body weight loss, comparable to other GLP1R/GIPR dual agonists
Bjornsson E, Kalaitzakis E, Olsson R
Clarifying whether resistance-associated molecular features are induced by treatment or already present before therapy is crucial for improving patient stratification