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Other reported or anticipated side effects based on Phase 2 data and the known pharmacology of the drug class include: Injection site reactions redness, bruising, or mild discomfort at the site of subcutaneous injection Fatigue commonly associated with caloric restriction and rapid weight loss Headache reported with GLP-1 receptor agonists as a class Increased heart rate (tachycardia) a known class effect of GLP-1 receptor agonists
Accessed April 2026
Wesley Chapel Spine & Sports Medicine offers it as part of a comprehensive weight loss plan
2019;7:e617
Bloating happens often with tirzepatide, though it is not always listed as the top side effect
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