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Previously, a study based on proteomic analysis had revealed marked transcriptional repression of other Nrf2-induced antioxidant proteins including CK2, ERK1/2, PKC, GPx, Mgst1, peroxiredoxin 3 (Prdx3), in both preclinical models and in human spinal MNs from ALS patients [253]

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p 20%) with gedatolisib-triple and -doublet therapy were stomatitis (69.2%, 59.6%), neutropenia (65.4%, 1.5%), nausea (43.8%, 43.1%%), rash (27.7%, 32.3%), vomiting (27.7%, 23.1%), and fatigue (22.3%, 20.8%)