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Circulation 143 (21), e984e1010

Sensitivity landmark analyses stratified by timeframe of semaglutide initiation Given that semaglutide was initially approved for type 2 diabetes, with initial obesity approval in 2021, it is possible that inclusion of non-diabetic patients could introduce indication bias in the previously described analyses, as non-diabetic patients enrolled before 2021 likely represent off-label use and may differ systematically from those treated after approval