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Its atherogenic effects include abnormalities in cholesterol and bile acid metabolism, which cause inflammation and foam cell production
By interacting with receptors in the brain and digestive system, GLP-1s help reduce appetite, manage cravings, and support healthier eating habits
Established on July 1, 1976, UCI Health has grown into a 1,461-bed health system that includes UCI Health Orange, UCI Health Irvine, four Community Network hospitals and a growing network of ambulatory care centers across Orange and Los Angeles counties
10.1038/emm.2007.66 133 JeongC
For this reason, researchers should design protocols with realistic endpoints focused on liver function, metabolic biomarkers, and nutrient status rather than dramatic body composition changes
The recent conclusion of major phase 3 trials for the oral glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide represents another notable setback in this endeavor (Scragg et al., 2025)
