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The IGF-1 MSIA-SRM provides a linear dynamic range spanning 11,500 ng/mL ( Figure 3 ), enabling a single assay to quantify IGF-1 over its biologically relevant concentrations and the ability to quantify as little as 5 femtomoles of IGF-1 from 40 mL human plasma
For patients, it marks a much-needed shift away from willpower-based narratives and toward understanding weight as something rooted in biology
Data availability statement The data of this study are available from the corresponding author upon reasonable request