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The total annual cost difference is substantial: NHS route : 9.90 monthly (or free if exempt) = approximately 119 annually, or 111.60 with PPC Private route : 150300 monthly = 1,8003,600 annually, plus consultation fees It is important to note that NHS access to GLP-1 medications for weight management remains limited due to NICE eligibility criteria and local commissioning decisions, which may necessitate private treatment for some patients who do not meet strict NHS criteria

26:1019-1028 (2017) Taloria D, Samanta S, Das S, Pututunda C

Where the Science Is Headed Now The next phase of the GLP-1 story is less about format and more about stability in the body over time, a shift that became tangible in December 2025 when the FDA approved Novo Nordisks oral semaglutide (Wegovy), the first daily GLP-1 pill cleared for obesity treatment

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Semaglutide has demonstrated therapeutic potential for MASLD/NASH and heart failure with preserved ejection fraction (HFpEF)