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Tumour tissue immunohistochemistry (IHC) staining was performed using standard techniques as described previously (Ma et al, 2005) with antibodies against the following proteins: HGF (Zymed-Invitrogen, Carlsbad, CA, USA), c-MET (3D4 monoclonal

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Across scenarios, both switching and dose escalation strategies were associated with higher expected weight loss compared with baseline regimens, with probabilities of benefit ( P [new better]) approaching 100% in most comparisons