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It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
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However, for most people, it can take a few months to notice a change in weight
Evidence supporting the involvement of activated microglia-mediated chronic neuroinflammation in PD includes: (1) Pro-inflammatory effects are often observed in activated microglia surrounding dopaminergic neurons, with the degree of microglial activation correlating with dopaminergic endings loss in PD (174, 175)
This shift represents a move toward treatments that work with the body rather than against it
doi: 10.1016/j.jfoodeng.2006.04.011 129
