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Changes in NNMT activity shouldnt be interpreted as producing predictable changes in NAD+ levels across all biological systems

The deficiency was more severe than expected People with advanced B12 deficiency, especially with neurological symptoms, often feel rough at the start of treatment because the underlying problem was significant

There is also recent data which suggest that genetic alterations of the receptor by which B12 is transported into nerve tissue and the brain, may lead to a lower B12 uptake

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Ellie, the R.N