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Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-I

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Shared signaling pathways, complementary effects on inflammation and oxidative stress, coordinated neuroprotection, and mutually reinforcing influences on body composition all point in the same direction

Vogel DG, Malekzadeh MH, Cornford ME, Schneider JA, Shields WD, Vinters HV (1990) Central nervous system involvement in nephropathic cystinosis

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In regard to the effective approach in combining pharmacological treatments with effective lifestyle modifications can indeed be challenging but holistic approaches offer a promising solution