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About 9 million Americans were taking a GLP-1 drug as of the end of 2022, a Trilliant Health analysis found
However it should be noted that the overall and off-label use of GLP-1R agonists in 2023 are likely underestimated in the published study, as it doesnt include the recently approved member of this group, tirzepatide (Mounjaro), which induces even greater weight loss than Ozempic
Macrovascular complications (CAD, stroke, PAD) result from accelerated atherosclerosis driven by dyslipidemia, inflammation, and oxidative stress
Yet, molecular mechanisms underlining GLP-1 mediated stimulation of insulin secretion are still not fully characterized
One notable difference is that tirzepatide is a dual-agonist (GLP-1 and GIP) while retatrutide is a triple-agonist (GLP-1, GIP, and glucagon)
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