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The AMPD2 gene is located on chromosome 1p13.3 and is composed of 20 exons that generate five alternatively spliced mRNAs that collectively encode four distinct protein isoforms

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95% CI [0.741.22]).41 BP reduction may account for the prevention of haemorrhagic stroke.42 However, elevated haematocrit was also observed in the EMPA-REG OUTCOME trial, which might predispose to ischaemic strokes.11,42,43 Although haemoconcentration improves cardiovascular outcomes, the higher blood viscosity may trigger thrombus formation.27,4244 Although weight loss should protect against ischaemic stroke, compensatory changes may limit weight loss in the long term.33 Although a harmful effect on stroke has not been confirmed, the protective effect on haemorrhagic stroke may mask the effect on ischaemia if both types of stroke are included as a composite endpoint.1618 Population-wide observational studies may help to evaluate the long-term risk of ischaemic strokes during SGLT2 inhibitor therapy