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In particular, LEAP2 (liver-expressed antimicrobial peptide 2), an endogenous antagonist of the ghrelin receptor GHSR, has emerged as a potential target for mitigating the weight regain often observed after discontinuation of GLP-1-based therapies [22,23]

Full therapeutic effects typically develop over 4-12 weeks depending on the severity and type of injury

peak tissue quality improvement at 1012 weeks