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Another well recognised neuropathological finding in AD is the accumulation of abnormally hyperphosphorylated Tau in degenerating neurons[325]

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In all the three structures, the densities of most ECL1 residues are invisible, whereas ECL2 and ECL3 are well-defined in the EM maps of GLP-1R and GIPR, and largely solved in GCGR except one short segment (D299G302) (Supplementary Fig

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