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Upon binding to the receptor, GLP-1 and its analogs also initiate a variety of additional anti-diabetic effects, including, but not limited to, reduction in gastric emptying, increase in satiety and inhibition of food motivated behavior, replenishment of insulin stores, as well as cytoprotective and anti-inflammatory actions on -cells (29)
Kumar P, Osahon O, Sekhar RV
In addition, some studies on recently marketed GLP-1 RAs such as dulaglutide (AWARD studies), albiglutide (HARMONY studies), and lixisenatide (GetGoal studies) included cardiovascular parameters as a part of their non-primary endpoints (Table 2)
Efectos gastrointestinales: Los efectos adversos ms comunes son de naturaleza gastrointestinal e incluyen nuseas (reportadas en 20-40% de los pacientes), vmitos, diarrea y estreimiento
The quantification was set to Robust LC (high precision) mode with normalization disabled, MBR enabled, protein inferences set to Genes and Heuristic protein inference turned off
The benefits extend beyond weight loss, with GLP-1 also shown to reduce the risk of cardiovascular events such as coronary artery disease and strokes, as well as prevent and improve type 2 diabetes
