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In addition, we determined structures of CydDC in the presence of a combination of heme and thiols (GSH, glutathione disulfide (GSSG), l-Cys) to assess whether these molecules may be heme-dependent cosubstrates
A 4K mid-density SNP panel was used for genotyping, producing 2,015 high-confidence SNPs after stringent filtering for GWAS
Titration governs tolerability fast 2-week ramp to 15 mg gave 24.5% AE-discontinuation (Frias 2018)
