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Renal Considerations Both medications require consideration in patients with kidney impairment: Meloxicam should be used cautiously in patients with reduced kidney function and is contraindicated in severe renal failure (not on dialysis), with a maximum dose of 7.5mg daily for patients on dialysis Wegovy-associated weight loss and potential dehydration (from gastrointestinal side effects) could theoretically affect renal function There is a particularly important risk of acute kidney injury with the 'triple whammy' combination of an NSAID, ACE inhibitor/ARB, and diuretic, which requires careful monitoring There is no evidence of a direct interaction affecting kidney function , but patients with pre-existing renal impairment should be monitored appropriately by their healthcare team

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Table 2: Summary of anaesthetic-related recommendations and considerations for case management to reduce risks of aspiration

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