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Researchers use the peptide to compare lipolytic and lipogenic balance under combined incretin/glucagon signaling versus single-pathway controls
Peptide signalling pathways and cellular communication mechanisms
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A smaller but notable group reports unexpected side effects
Discussion The crystallized inactive GLP-1R structure is not compatible with the known binding mode of GLP-1 requiring a conformational change of the ECD and a rearrangement of the TMD to enable binding of GLP-1
This creates a paradox where a medication designed to improve metabolic health may undermine one of the mechanisms through which metabolic health is maintained
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