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The most common clinical manifestations include urticaria, pruritus, and flushing, often accompanied by mild wheezing or dyspnea, particularly in individuals with asthma or reactive airway disease
The ATP-grasp fold is conserved within the ATP-grasp superfamily and is characterized by two alpha helices and beta sheets that hold onto the ATP molecule between them
Herman, A
References: National Institutes of Health, Office of Dietary Supplements