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Yu et al
GS had no effect on COX-1 mRNA expression in either the absence or presence of IL-1 (Figure 2A, 2B)
For example, in pancreatic cancer, the inflammasome component NLRP4 mediates PARPi resistance by promoting NOXO1 expression, which inhibits nuclear translocation of SIRT7, thereby enhancing ROS-induced autophagy and reactivating DDR via reduced H2AX accumulation and impaired BRCA1RAD51 complex formation
References Brines M, et al
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