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Altogether, muscle loss during GLP1RAs therapy is multifactorial, involving reduced protein intake and negative energy balance, hormonal adaptations, impaired mTOR signaling and protein synthesis, increased proteolysis and potential mitochondrial adaptations, and age, frailty, and physical inactivity as modifiers (Fig
Semaglutide also remains the most prescribed AOM (brand name Wegovy), followed by AOM tirzepatide (Zepbound)
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