J Neurosurg 136:17901795, 2022 Cerebrospinal fluid (CSF) shunting in idiopathic intracranial hypertension (IIH) is associated with high complication rates, primarily because of the technical challenges that are related to small ventricles and a large body habitus
Due to their short plasma half-life t1/2 (~2-4 h), they are administered once or twice daily
As a result, many researchers and clinicians now advocate for more cautious, limited use during pregnancy
Injectable peptides are the standard option because they have greater bioavailability and efficacy than oral treatments
In contrast, A1298C results in a smaller reduction in enzyme activity through an unknown mechanism
At three, six, nine and 12 months following semaglutide initiation, women using hormone therapy experienced approximately 30% greater total body weight loss than the non-hormone therapy users