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Liver benefits are being measured but as secondary outcomes

50 A link between circulating levels of BAs and glucose metabolism had been shown by multiple studies, which demonstrated that BAs regulate glucose homeostasis through activation of GPBAR1/TGR5

40 , D930D934 (2012)

For off-label use, insurance coverage is typically not guaranteed, and treatment is usually self-pay

Other serious side effects include increased blood pressure and heart rate and, less commonly, liver damage or hepatitis, vision problems, increased risk of low blood sugar in people with type 2 diabetes, or manic episodes