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This can result in a reduced need for thyroid hormone replacement, particularly in patients who initially required higher doses due to obesity-related factors like increased inflammation or altered hormone metabolism

While tirzepatide has been proven effective on its own, there is limited research on the safety and effectiveness of using it in combination with other weight loss medications such as phentermine , bupropion/naltrexone, or orlistat

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SAEs were not significantly increased with any OMM, except for naltrexone plus bupropion, which showed a higher SAE rate compared to placebo

Folate Supplements Doses: Folate supplements are often included in multivitamins or prescribed separately if needed

These results highlighted the significant role of peripheral CB1 inhibition to induce dose-dependent weight loss without reliance on central CB1 inhibition, and strongly favor nimacimabs distinct positioning within the class compared to central CB1 inhibition