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MC1R in peripheral melanocytes driving melanogenesis, and central MC3R/MC4R in hypothalamic and limbic circuits driving sexual behaviour
Not suitable for pregnant or breastfeeding women unless advised by a healthcare professional
If no improvement occurs after 3-4 weeks at appropriate doses, product quality may be an issue, or the condition may not respond to this approach
Choosing Between Semaglutide and Tirzepatide for Non-Diabetic Use Both semaglutide and tirzepatide are safe and effective in non-diabetic populations, but tirzepatide often produces slightly greater weight loss due to its dual-pathway mechanism
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WHO 2011a
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