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Free radicals are byproducts of normal bodily processes and external factors like pollution, stress, and unhealthy lifestyles

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On this ground the WHO updated its DR-TB treatment guidelines in 2022 (WHO Consolidated Guidelines on Tuberculosis, 2024), recommending the 6-month BPaL-M regimen for MDR/Rifampicin-Resistant (RR)-TB in patients unexposed to bedaquiline, pretomanid, or linezolid (Johnson et al., 2024)

Cell 81 , 691707.e6 (2021)

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation