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Phase 2 trial data published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023) reported mean weight reductions of up to approximately 24% over 48 weeks in adults with obesity notably higher than results seen with currently approved agents

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It could be up to 2 years before you see the full effect of semaglutide on your body

Non-response at 1.5mg indicates either receptor polymorphism, prior desensitisation from chronic melanocortin agonist exposure, or incorrect administration technique

Both require IGF-1 monitoring to avoid supraphysiological growth hormone levels

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