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In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression
The gut lining can take a beating during extended use of GLP-1 class medications, and some researchers believe that supporting gut integrity proactively leads to better long-term tolerance
Specific diseases or conditions, such as celiac disease or Crohn's disease, or even those who have undergone gastric surgery may not properly absorb Vitamin B12
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Last reviewed 2026-05-29
