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Based on this, in the subsequent I/R- and TMT-induced myocardial injury model, the drug not only enhanced GSH levels and GPX and GST activities to lower oxidative damage but also reduced TMT-induced pyroptosis and I/R-mediated apoptosis [205,206,207]

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According to NICE NG28, GLP-1 receptor agonist treatment should only be continued if there is beneficial metabolic response (HbA1c reduction of at least 11 mmol/mol [1.0%] and weight loss of at least 3% of initial body weight at 6 months)

The condition affects approximately 5% to 10% of the US population, though clinically significant cases requiring treatment are less common