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403 POLG mutations can also disrupt mitochondrial biogenesis, as well as mitophagy, leading to astrocytic neurotoxicity and a loss of supportive functions

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Bile acids serve as a crucial pathway for cholesterol elimination through excretion in feces helping to decrease circulating cholesterol levels and reduce the risk of plaque accumulation (193)

doi: 10.1016/j.ahj.2018.03.030 17 GersteinHCColhounHMDagenaisGRDiazRLakshmananMPaisPet al

doi:10.3389/fendo.2012.00141 25

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