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G., McGonigle, D

In the liver, a particular metabolic pathway called transsulfuration permits the supply of cysteine by conversion of an essential amino acid: methionine

Human oral bioavailability is unknown, so the animal result cannot prove how much a person would absorb or support a route conversion

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We treated human TC cells (K1, MDA-T68, MDA-T32, TPC1) with (1S,3R)-RSL3 (RSL3), a small-molecule inhibitor of GPX4 and examined the effects on ferroptosis, tumor cell survival and migration, spheroid formation, oxidative stress, DNA damage repair response, and mTOR signaling pathway in vitro

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