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Conclusion Our study suggests that among older adults with type 2 diabetes treated with levothyroxine, initiation and continued use of GLP-1RA was associated with an increased risk of atrial fibrillation or flutter compared to SGLT2 inhibitors, without an elevation on stroke risk
Importantly, such adaptability creates synthetic vulnerabilities that may be exploited through rational drug combinations targeting parallel or downstream nodes
This proactive approach helps identify patients who may benefit most from alternative weight loss strategies or require closer monitoring during treatment
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The exact mechanism is not fully established but may relate to glucagon receptor activity in peripheral neural tissue [3]
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