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These include: Endogenous reactive metabolites such as products arising from oxidative metabolism of lipids, nucleic acids and catecholamines Xenobiotics which are not normally found in the body and can include naturally occurring compounds or they can be man made in origin such as drugs or environmental pollutants Heavy metals such as mercury, lead, cadmium and arsenic The chemical reactivity of many of these compounds cause interference with the normal biological processes and hence they are toxic

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Its tough to say, so we definitely need more hard science to look at that in a more objective way, Spittler said

The reasons: Low lower limit : In most countries, the lower end of the standard vitamin B12 range (100-250 pg/mL) is too low, often missing severe deficiencies