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Both agents target different pathways in glucose control and appetite regulation, raising the question of whether combining them amplifies results or creates safety concerns

[102] evaluated the effects of a shiitake-derived -D-glucan preparation on lipid metabolism, immune markers, and gut microbiota in a double-blind, placebo-controlled trial involving 52 adults with untreated mild hypercholesterolemia

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They usually improve over time as your body adjusts

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