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mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
It may accelerate the callus formation process, enhancing the strength and resilience of healed bones and potentially offsetting complications arising from fractures
Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations 8-OH-dg: 8-hydroxy-2-deoxyguanosine AM: airway macrophage BAL: bronchoalveolar lavage ELF: epithelial lining fluid GSH: glutathione (reduced form) GSSG: glutathione disulfide (oxidized form) HAT: histone acetyltransferase HDAC: histone deacetylase ICS: inhaled corticosteroid MDA: malondialdehyde PARP: poly (ADP-ribose) polymerase References Fitzpatrick AM, Gaston BM, Erzurum SC, Teague WG 2006 Features of severe asthma in school-age children: atopy and increased exhaled nitric oxide
(2020) New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8, Curr
Retrieved March 15, 2025, from National Health Service
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